4RA0
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Growth arrest-specific protein 6 | polymer | 401 | 44441.9 | 2 | UniProt (Q14393-2) Pfam (PF00054) Pfam (PF02210) UniProt (by SIFTS) (Q14393) In PDB | Homo sapiens (human) | GAS-6, AXL receptor tyrosine kinase ligand |
| 2 | C, D | Tyrosine-protein kinase receptor UFO | polymer | 195 | 21167.5 | 2 | UniProt (P30530) Pfam (PF13927) In PDB | Homo sapiens (human) | AXL oncogene |
| 3 | E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | C, D | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 7 | C, D | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
C, D: 26 - 220 (UniProt: P30530)
| PDB | External Database | Details |
|---|---|---|
| Ser 32 | Gly 39 | conflict |
| Gly 87 | Asp 94 | conflict |
| Ala 92 | Val 99 | conflict |
| Arg 127 | Gly 134 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131218.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 425.1 | |
| All* | Total formula weight | 132492.7 |
