4R9Y

Crystal structure of KKOFab in complex with platelet factor 4

Summary for 4R9Y

• Entry DOI: 10.2210/pdb4r9y/pdb
• Related: 4R97 4R9W
• Descriptor: Platelet factor 4, Platelet factor 4 antibody KKO light chain, Platelet factor 4 antibody KKO heavy chain (3 entities in total)
• Functional Keywords: kko, pf4, hit, immunoglobulin, cxc chemokine, antibody, antigen, blood, immune system-cytokine complex, immune system/cytokine
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P02776
• Total number of polymer chains: 8
• Total formula weight: 125212.63

Authors

Cai, Z.,Zhu, Z.,Liu, Q.,Greene, M.I. (deposition date: 2014-09-08, release date: 2015-12-16, Last modification date: 2017-11-22)

• Primary citation: Cai, Z.,Yarovoi, S.V.,Zhu, Z.,Rauova, L.,Hayes, V.,Lebedeva, T.,Liu, Q.,Poncz, M.,Arepally, G.,Cines, D.B.,Greene, M.I.; Atomic description of the immune complex involved in heparin-induced thrombocytopenia.; Nat Commun, 6:8277-8277, 2015; PubMed: 26391892; DOI: 10.1038/ncomms9277

Experimental method

X-RAY DIFFRACTION (4.11 Å)