4R5H

Crystal structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide-Adenine-Dinucleotide-Phosphate and 3-carboxy-propenyl-phthalic acid

4R5H の概要

• エントリーDOI: 10.2210/pdb4r5h/pdb
• 関連するPDBエントリー: 4R3N 4R3W 4R41 4R4J 4R51 4R54 4R5M
• 分子名称: Aspartate-semialdehyde dehydrogenase, 1,2-ETHANEDIOL, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: rossmann fold, oxidoreductase, nadp
• 由来する生物種: Streptococcus pneumoniae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82356.58

構造登録者

Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. (登録日: 2014-08-21, 公開日: 2014-12-10, 最終更新日: 2023-09-20)

• 主引用文献: Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E.; A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.; Acta Crystallogr.,Sect.D, 70:3244-3252, 2014; PubMed: 25478842; DOI: 10.1107/S1399004714023979

実験手法

X-RAY DIFFRACTION (1.8 Å)