4R1V

Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

4R1V の概要

• エントリーDOI: 10.2210/pdb4r1v/pdb
• 関連するPDBエントリー: 4R1Y
• 分子名称: Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, GAMMA-BUTYROLACTONE, ... (4 entities in total)
• 機能のキーワード: protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33742.21

構造登録者

Blaukat, A.,Bladt, F.,Friese-Hamim, M.,Knuehl, C.,Fittschen, C.,Graedler, U.,Meyring, M.,Dorsch, D.,Stieber, F.,Schadt, O. (登録日: 2014-08-07, 公開日: 2015-03-18, 最終更新日: 2024-02-28)

• 主引用文献: Dorsch, D.,Schadt, O.,Stieber, F.,Meyring, M.,Gradler, U.,Bladt, F.,Friese-Hamim, M.,Knuhl, C.,Pehl, U.,Blaukat, A.; Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:1597-1602, 2015; PubMed: 25736998; DOI: 10.1016/j.bmcl.2015.02.002

実験手法

X-RAY DIFFRACTION (1.2 Å)