4R0X

Allosteric coupling of conformational transitions in the FK1 domain of FKBP51 near the site of steroid receptor interaction

Summary for 4R0X

DescriptorPeptidyl-prolyl cis-trans isomerase FKBP5 (2 entities in total)
Functional Keywordsfk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, isomerase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q13451
Total number of polymer chains1
Total molecular weight13487.48
Authors
LeMaster, D.M.,Mustafi, S.M.,Brecher, M.,Zhang, J.,Heroux, A.,Li, H.M.,Hernandez, G. (deposition date: 2014-08-02, release date: 2015-05-13, Last modification date: 2015-07-22)
Primary citation
LeMaster, D.M.,Mustafi, S.M.,Brecher, M.,Zhang, J.,Heroux, A.,Li, H.,Hernandez, G.
Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.
J.Biol.Chem., 290:15746-15757, 2015
PubMed: 25953903 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.650655
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1672004.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4r0x
no rotation
Molmil generated image of 4r0x
rotated about x axis by 90°
Molmil generated image of 4r0x
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4r0x
no rotation
Molmil generated image of 4r0x
rotated about x axis by 90°
Molmil generated image of 4r0x
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4r0x.pdb1.gz [43.03 KB])
Coordinate files for Biological unit (4r0x.pdb2.gz [84.87 KB])
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan