4R0A

Crystal structure of human TLR8 in complex with uridine mononucleoside

4R0A の概要

• エントリーDOI: 10.2210/pdb4r0a/pdb
• 関連するPDBエントリー: 4R07 4R08 4R09
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(2-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: leucine rich repeat, glycosylation, innate immunity, rna recognition, ssrna, rna receptor, rna binding, antiviral binding, antitumor drug binding, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 96549.79

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2014-07-30, 公開日: 2015-01-14, 最終更新日: 2020-07-29)

• 主引用文献: Tanji, H.,Ohto, U.,Shibata, T.,Taoka, M.,Yamauchi, Y.,Isobe, T.,Miyake, K.,Shimizu, T.; Toll-like receptor 8 senses degradation products of single-stranded RNA.; Nat.Struct.Mol.Biol., 22:109-115, 2015; PubMed: 25599397; DOI: 10.1038/nsmb.2943

実験手法

X-RAY DIFFRACTION (1.9 Å)