4R0A

Crystal structure of human TLR8 in complex with uridine mononucleoside

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002224	biological_process	toll-like receptor signaling pathway
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	800
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU27-THR827

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site_id	SWS_FT_FI2
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN115
A	ASN160
A	ASN247
A	ASN285
A	ASN29
A	ASN42
A	ASN358
A	ASN362
A	ASN416
A	ASN443
A	ASN582
A	ASN752

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN80
A	ASN88

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site_id	SWS_FT_FI4
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111

Chain	Residue	Details
A	ASN293
A	ASN395
A	ASN511
A	ASN546
A	ASN590
A	ASN640
A	ASN680

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