4R0A
Crystal structure of human TLR8 in complex with uridine mononucleoside
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Toll-like receptor 8 | polymer | 811 | 92835.4 | 1 | UniProt (Q9NR97) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | B (B) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(2-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | ||||
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | ||||
| 4 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | ||||
| 5 | E (A) | URIDINE | non-polymer | 244.2 | 1 | Chemie (URI) PubChem (1177) PubChem (6029) PubChem (18323) PubChem (177679014) PubChem (40428662) PubChem (44450699) PubChem (45356795) PubChem (45358305) PubChem (46780471) PubChem (46875324) PubChem (57157461) PubChem (57291238) PubChem (57416896) PubChem (66682873) PubChem (68438530) PubChem (68442208) PubChem (453551) PubChem (466466) PubChem (638039) PubChem (643973) PubChem (1521749) PubChem (170274) PubChem (89495556) PubChem (92131731) PubChem (6604651) PubChem (10169826) PubChem (11064619) PubChem (6559159) PubChem (7059436) PubChem (7059437) PubChem (7059438) PubChem (7059439) PubChem (119106346) PubChem (9859650) PubChem (12219138) PubChem (12219139) PubChem (130312966) PubChem (133687563) PubChem (134694357) PubChem (147417237) PubChem (164540240) PubChem (168266025) PubChem (171699408) | |||
| 6 | F, G, H, I, J... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 7 | M (A) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence modifications
A: 27 - 827 (UniProt: Q9NR97)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Glu 828 | - | expression tag |
| Phe 829 | - | expression tag |
| Leu 830 | - | expression tag |
| Val 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 92835.4 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1921.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1792.7 | |
| All* | Total formula weight | 96549.8 |
