4QZI

Mouse Tdt, F401A mutant, in complex with a DSB substrate and Zn2+

Summary for 4QZI

• Entry DOI: 10.2210/pdb4qzi/pdb
• Related: 1JMS 4I27 4QZ8 4QZ9 4QZA 4QZB 4QZC 4QZD 4QZE 4QZF 4QZG 4QZH
• Descriptor: DNA nucleotidylexotransferase, 5'-D(*AP*AP*AP*AP*AP*C)-3', 5'-D(*TP*TP*TP*TP*TP*GP*GP*G)-3', ... (8 entities in total)
• Functional Keywords: terminal deoxynucleotidyltransferase, nucleus, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (mouse); More
• Cellular location: Isoform TDT-S: Nucleus. Isoform TDT-L: Cytoplasm. Nucleus : P09838
• Total number of polymer chains: 4
• Total formula weight: 52341.33

Authors

Gouge, J.,Delarue, M. (deposition date: 2014-07-27, release date: 2015-06-10, Last modification date: 2023-09-20)

• Primary citation: Gouge, J.,Rosario, S.,Romain, F.,Poitevin, F.,Beguin, P.,Delarue, M.; Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.; Embo J., 34:1126-1142, 2015; PubMed: 25762590; DOI: 10.15252/embj.201489643

Experimental method

X-RAY DIFFRACTION (2.65 Å)