4QTI
Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12
Summary for 4QTI
Entry DOI | 10.2210/pdb4qti/pdb |
Related | 4QTH |
Descriptor | anti-uPAR antibody, heavy chain, anti-uPAR antibody, light chain, Urokinase plasminogen activator surface receptor (3 entities in total) |
Functional Keywords | allosteric regulation, cell surface, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane . Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 2: Secreted : Q03405 |
Total number of polymer chains | 3 |
Total formula weight | 79177.14 |
Authors | |
Primary citation | Zhao, B.,Gandhi, S.,Yuan, C.,Luo, Z.,Li, R.,Gardsvoll, H.,de Lorenzi, V.,Sidenius, N.,Huang, M.,Ploug, M. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. J.Mol.Biol., 427:1389-1403, 2015 Cited by PubMed: 25659907DOI: 10.1016/j.jmb.2015.01.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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