4QSU

Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymine

Summary for 4QSU

Related4QSP 4QSQ 4QSR 4QSS 4QST 4QSV 4QSW 4QSX
DescriptorATPase family AAA domain-containing protein 2, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsstructural genomics consortium (sgc), signaling protein, bromodomain, actyl-lysine binding, atpase family aaa domain-containing protein 2, epigenetics
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q6PL18
Total number of polymer chains1
Total molecular weight16206.23
Authors
Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-06, release date: 2014-07-23, Last modification date: 2015-01-14)
Primary citation
Chaikuad, A.,Petros, A.M.,Fedorov, O.,Xu, J.,Knapp, S.
Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
MedChemComm, 5:1843-1848, 2014
DOI: 10.1039/C4MD00237G
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209500.8%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution