4QSP

Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with acetyl-lysine

Summary for 4QSP

• Entry DOI: 10.2210/pdb4qsp/pdb
• Related: 4QSQ 4QSR 4QSS 4QST 4QSU 4QSV 4QSW 4QSX
• Descriptor: ATPase family AAA domain-containing protein 2, N(6)-ACETYLLYSINE, SULFATE ION, ... (5 entities in total)
• Functional Keywords: structural genomics consortium (sgc), signaling protein, bromodomain, actyl-lysine binding, atpase family aaa domain-containing protein 2, epigenetics
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q6PL18
• Total number of polymer chains: 1
• Total formula weight: 16392.48

Authors

Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-06, release date: 2014-07-23, Last modification date: 2023-12-06)

• Primary citation: Chaikuad, A.,Petros, A.M.,Fedorov, O.,Xu, J.,Knapp, S.; Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain; MedChemComm, 5:1843-1848, 2014; DOI: 10.1039/C4MD00237G

Experimental method

X-RAY DIFFRACTION (1.6 Å)