4QST

Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 1-methylquinolin 2-one

4QST の概要

• エントリーDOI: 10.2210/pdb4qst/pdb
• 関連するPDBエントリー: 4QSP 4QSQ 4QSR 4QSS 4QSU 4QSV 4QSW 4QSX
• 分子名称: ATPase family AAA domain-containing protein 2, 1-METHYLQUINOLIN-2(1H)-ONE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: structural genomics consortium (sgc), signaling protein, bromodomain, actyl-lysine binding, atpase family aaa domain-containing protein 2, epigenetics
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q6PL18
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16735.84

構造登録者

Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2014-07-06, 公開日: 2014-07-23, 最終更新日: 2023-09-20)

• 主引用文献: Chaikuad, A.,Petros, A.M.,Fedorov, O.,Xu, J.,Knapp, S.; Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain; MedChemComm, 5:1843-1848, 2014; DOI: 10.1039/C4MD00237G

実験手法

X-RAY DIFFRACTION (2.05 Å)