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4QQT

Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain

Summary for 4QQT
Entry DOI10.2210/pdb4qqt/pdb
Related4QQ5 4QQC 4QQJ
DescriptorFibroblast growth factor receptor 4, SULFATE ION (2 entities in total)
Functional Keywordskinase domain fold, cell signaling, phosphotransferase, plasmamembrane, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455
Total number of polymer chains1
Total formula weight36319.63
Authors
Huang, Z.,Mohammadi, M. (deposition date: 2014-06-29, release date: 2014-10-29, Last modification date: 2023-09-20)
Primary citationHuang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M.
DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10:299-309, 2015
Cited by
PubMed: 25317566
DOI: 10.1021/cb500674s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.501 Å)
Structure validation

217705

數據於2024-03-27公開中

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