4QQT

Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fibroblast growth factor receptor 4	polymer	323	36127.5	1	UniProt (P22455) Pfam (PF07714)	Homo sapiens (human)	FGFR-4
2	B, C (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A: 445 - 753 (UniProt: P22455)

PDB	External Database	Details
Met 431	-	initiating methionine
Gly 432	-	expression tag
Ser 433	-	expression tag
Ser 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
Ser 441	-	expression tag
Gln 442	-	expression tag
Asp 443	-	expression tag
Pro 444	-	expression tag
Ala 477	Cys 477	engineered mutation
Glu 664	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36127.5
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	36319.6

*Water molecules are not included.