4QKX

Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody

4QKX の概要

• エントリーDOI: 10.2210/pdb4qkx/pdb
• 分子名称: Beta-2 adrenergic receptor, R9 protein, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: 7-transmembrane helices, signal transduction, g proteins, membrane, membrane protein-immune system complex, membrane protein/immune system
• 由来する生物種: Enterobacteria phage T4; 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P07550
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66810.86

構造登録者

Weichert, D.,Kruse, A.C.,Manglik, A.,Hiller, C.,Zhang, C.,Huebner, H.,Kobilka, B.K.,Gmeiner, P. (登録日: 2014-06-10, 公開日: 2014-07-23, 最終更新日: 2017-06-28)

• 主引用文献: Weichert, D.,Kruse, A.C.,Manglik, A.,Hiller, C.,Zhang, C.,Hubner, H.,Kobilka, B.K.,Gmeiner, P.; Covalent agonists for studying G protein-coupled receptor activation.; Proc.Natl.Acad.Sci.USA, 111:10744-10748, 2014; PubMed: 25006259; DOI: 10.1073/pnas.1410415111

実験手法

X-RAY DIFFRACTION (3.3 Å)