4QKN
Crystal structure of FTO bound to a selective inhibitor
Summary for 4QKN
| Entry DOI | 10.2210/pdb4qkn/pdb |
| Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE, 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid, ... (6 entities in total) |
| Functional Keywords | jellyroll folding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : Q9C0B1 |
| Total number of polymer chains | 1 |
| Total formula weight | 55297.94 |
| Authors | Yang, C.-G.,Huang, Y.,Gan, J. (deposition date: 2014-06-07, release date: 2014-12-03, Last modification date: 2024-05-29) |
| Primary citation | Huang, Y.,Yan, J.,Li, Q.,Li, J.,Gong, S.,Zhou, H.,Gan, J.,Jiang, H.,Jia, G.F.,Luo, C.,Yang, C.G. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res., 43:373-384, 2015 Cited by PubMed: 25452335DOI: 10.1093/nar/gku1276 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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