4QKN
Crystal structure of FTO bound to a selective inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 476 | 54707.7 | 1 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB | Homo sapiens (human) | Fat mass and obesity-associated protein |
2 | A | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
3 | A | 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid | non-polymer | 296.1 | 1 | Chemie (JMS) | |||
4 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 32 - 503 (UniProt: Q9C0B1)
PDB | External Database | Details |
---|---|---|
Gly 28 | - | expression tag |
Ser 29 | - | expression tag |
His 30 | - | expression tag |
Met 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54707.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 590.3 | |
All* | Total formula weight | 55297.9 |