4QKN
Crystal structure of FTO bound to a selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 476 | 54707.7 | 1 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) | Homo sapiens (human) | Fat mass and obesity-associated protein |
| 2 | B (A) | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
| 3 | C (A) | 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid | non-polymer | 296.1 | 1 | Chemie (JMS) | |||
| 4 | D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 32 - 503 (UniProt: Q9C0B1)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
| Met 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54707.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 590.3 | |
| All* | Total formula weight | 55297.9 |
