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4QKN

Crystal structure of FTO bound to a selective inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAlpha-ketoglutarate-dependent dioxygenase FTOpolymer47654707.71UniProt (Q9C0B1)
Pfam (PF12933)
Pfam (PF12934)
In PDB
Homo sapiens (human)Fat mass and obesity-associated protein
2AN-OXALYLGLYCINEnon-polymer147.11Chemie (OGA)
3A2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acidnon-polymer296.11Chemie (JMS)
4AMANGANESE (II) IONnon-polymer54.91Chemie (MN)
5AGLYCEROLnon-polymer92.11Chemie (GOL)
6waterwater18.073Chemie (HOH)
Sequence modifications
A: 32 - 503 (UniProt: Q9C0B1)
PDBExternal DatabaseDetails
Gly 28-expression tag
Ser 29-expression tag
His 30-expression tag
Met 31-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight54707.7
Non-Polymers*Number of molecules4
Total formula weight590.3
All*Total formula weight55297.9
*Water molecules are not included.

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PDB entries from 2024-06-12

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