4QFG

Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator

Summary for 4QFG

• Entry DOI: 10.2210/pdb4qfg/pdb
• Related: 4QFS 4QFT
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• Functional Keywords: cbm, kinase, ampk, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cytoplasm : P54645
• Total number of polymer chains: 3
• Total formula weight: 119466.80

Authors

Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2014-05-20, release date: 2014-08-06, Last modification date: 2017-11-22)

• Primary citation: Calabrese, M.F.,Rajamohan, F.,Harris, M.S.,Caspers, N.L.,Magyar, R.,Withka, J.M.,Wang, H.,Borzilleri, K.A.,Sahasrabudhe, P.V.,Hoth, L.R.,Geoghegan, K.F.,Han, S.,Brown, J.,Subashi, T.A.,Reyes, A.R.,Frisbie, R.K.,Ward, J.,Miller, R.A.,Landro, J.A.,Londregan, A.T.,Carpino, P.A.,Cabral, S.,Smith, A.C.,Conn, E.L.,Cameron, K.O.,Qiu, X.,Kurumbail, R.G.; Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.; Structure, 22:1161-1172, 2014; PubMed: 25066137; DOI: 10.1016/j.str.2014.06.009

Experimental method

X-RAY DIFFRACTION (3.46 Å)