4QF9

Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution

4QF9 の概要

• エントリーDOI: 10.2210/pdb4qf9/pdb
• 分子名称: Glutamate receptor ionotropic, kainate 1, (2S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: kainate receptor ligand-binding domain, gluk1-s1s2, antagonist, membrane protein
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P22756
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89258.59

構造登録者

Kristensen, C.M.,Frydenvang, K.,Kastrup, J.S. (登録日: 2014-05-20, 公開日: 2015-04-22, 最終更新日: 2023-09-20)

• 主引用文献: Demmer, C.S.,Moller, C.,Brown, P.M.,Han, L.,Pickering, D.S.,Nielsen, B.,Bowie, D.,Frydenvang, K.,Kastrup, J.S.,Bunch, L.; Binding Mode of an alpha-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1.; ACS Chem Neurosci, 6:845-854, 2015; PubMed: 25856736; DOI: 10.1021/acschemneuro.5b00038

実験手法

X-RAY DIFFRACTION (2.28 Å)