4QCL

Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP

Summary for 4QCL

• Entry DOI: 10.2210/pdb4qcl/pdb
• Descriptor: DNA polymerase alpha catalytic subunit, RNA PRIMER, DNA TEMPLATE, ... (10 entities in total)
• Functional Keywords: b-family dna polymerase, dna replication, transferase-dna-rna complex, transferase/dna/rna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P09884
• Total number of polymer chains: 3
• Total formula weight: 116555.27

Authors

Baranovskiy, A.G.,Suwa, Y.,Babayeva, N.D.,Gu, J.,Tahirov, T.H. (deposition date: 2014-05-12, release date: 2014-11-26, Last modification date: 2024-02-28)

• Primary citation: Baranovskiy, A.G.,Duong, V.,Babayeva, N.D.,Zhang, Y.,Pavlov, Y.,Anderson, K.,Tahirov, T.H.; Activity and fidelity of human DNA polymerase alpha depend on primer structure; J.Biol.Chem., 2018

Experimental method

X-RAY DIFFRACTION (2.2 Å)