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4QCL

Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A1902975biological_processmitotic DNA replication initiation
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE DCP A 1301
ChainResidue
AASP860
AMG1302
AZN1303
AHOH1430
AHOH1446
AHOH1448
AHOH1470
AHOH1475
AHOH1597
AHOH1601
BDC11
APHE861
CDG110
CDG111
AASN862
ASER863
ALEU864
ATYR865
AARG922
ALYS950
AASP1004

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1302
ChainResidue
AASP860
APHE861
AASP1004
ADCP1301
AZN1303

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 1303
ChainResidue
AASP860
AASP1004
ADCP1301
AMG1302
AHOH1516
AHOH1601

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1304
ChainResidue
AHIS342
AHIS342
AGLU500
AGLU500

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 1305
ChainResidue
ACYS1224
AGLU1225
AILE1227
AILE1230
AHOH1510

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 1PE A 1306
ChainResidue
AVAL340
APHE341
APRO504
AALA516
AGLU517
AHOH1602
AHOH1623
AHOH1627
AHOH1653

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1307
ChainResidue
ALYS437
ATYR797
ATYR801
AILE802
AVAL803
AHOH1512

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN B 501
ChainResidue
BG6
BHOH610
BHOH615

Functional Information from PROSITE/UniProt
site_idPS00116
Number of Residues9
DetailsDNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI
ChainResidueDetails
ATYR1000-ILE1008

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P33609","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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