4QCL
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase alpha catalytic subunit | polymer | 922 | 105583.8 | 1 | UniProt (P09884) Pfam (PF03104) Pfam (PF00136) | Homo sapiens (human) | DNA polymerase alpha catalytic subunit p180 |
| 2 | B (B) | RNA PRIMER | polymer | 11 | 3521.2 | 1 | |||
| 3 | C (C) | DNA TEMPLATE | polymer | 21 | 6423.2 | 1 | |||
| 4 | D (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G, K (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 7 | H (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 8 | I (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 9 | J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 10 | L, M, N (A, B, C) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A: 336 - 1257 (UniProt: P09884)
| PDB | External Database | Details |
|---|---|---|
| Ala 516 | Val 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 115528.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1027.1 | |
| All* | Total formula weight | 116555.3 |
