4QBS

Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide

Summary for 4QBS

• Entry DOI: 10.2210/pdb4qbs/pdb
• Related: 4QBQ 4QBR
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, Histone H3, ZINC ION, ... (5 entities in total)
• Functional Keywords: zinc finger, histone binding, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q9Y6K1
• Total number of polymer chains: 2
• Total formula weight: 16854.27

Authors

Wang, H.,Li, H. (deposition date: 2014-05-08, release date: 2015-05-13, Last modification date: 2024-10-30)

• Primary citation: Noh, K.,Wang, H.,Kim, H.,Wenderski, W.,Fang, F.,Li, C.,Dewell, S.,Wu, X.,Ferris, A.,Hughes, S.H.,Zheng, D.,Melnick, A.M.,Patel, D.J.,Li, H.,Allis, C.D.; Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)