4QBS

Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006306	biological_process	DNA methylation
A	0010468	biological_process	regulation of gene expression

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	CYS549
A	CYS554
A	CYS583
A	CYS586

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 702

Chain	Residue
A	CYS537
A	CYS540
A	CYS559
A	CYS562

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 703

Chain	Residue
A	CYS497
A	CYS514
A	CYS517
A	CYS494

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 704

Chain	Residue
A	GLY587
A	GLY587
A	HIS588
A	HIS588
A	LYS589
A	LYS589
A	TYR592
A	HOH898
A	HOH898

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Zinc finger: {"description":"GATA-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Zinc finger: {"description":"PHD-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	Region: {"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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