4QBS
Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA (cytosine-5)-methyltransferase 3A | polymer | 138 | 15705.1 | 1 | UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) | Homo sapiens (human) | Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA |
| 2 | B (P) | Histone H3 | polymer | 7 | 856.9 | 1 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | G, H (A, P) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 476 - 611 (UniProt: Q9Y6K1)
| PDB | External Database | Details |
|---|---|---|
| Gly 474 | - | expression tag |
| Ser 475 | - | expression tag |
| Arg 545 | Glu 545 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 16562.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 292.3 | |
| All* | Total formula weight | 16854.3 |
