4QBB

Structure of the foot-and-mouth disease virus leader proteinase in complex with inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4-CARBAMIMIDAMIDOBUTYL)AMINO]-4-METHYL-1-OXOPENTAN-2-YL}AMINO)-3-HYDROXY-4-OXOBUTANOYL]-L-ARGINYL-L-PROLINAMIDE)

Summary for 4QBB

• Entry DOI: 10.2210/pdb4qbb/pdb
• Related: 1QMY
• Descriptor: Leader protease, POTASSIUM ION, N~2~-[(3S)-4-({(2R)-1-[(4-carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}amino)-3-hydroxy-4-oxobutanoyl]-L-arginyl-L-prolinamide, ... (5 entities in total)
• Functional Keywords: papain-like cysteine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Foot-and-mouth disease virus (FMDV)
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03305
• Total number of polymer chains: 3
• Total formula weight: 59135.22

Authors

Grishkovskaya, I.,Steinberger, J.,Cencic, R.,Juliano, M.A.,Juliano, L.,Skern, T. (deposition date: 2014-05-07, release date: 2014-11-05)

• Primary citation: Steinberger, J.,Grishkovskaya, I.,Cencic, R.,Juliano, L.,Juliano, M.A.,Skern, T.; Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage.; Virology, 468-470C:397-408, 2014; PubMed: 25240326; DOI: 10.1016/j.virol.2014.08.023

Experimental method

X-RAY DIFFRACTION (1.6 Å)