4QAF

Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)

4QAF の概要

• エントリーDOI: 10.2210/pdb4qaf/pdb
• 分子名称: Lipocalin-1, Vascular endothelial growth factor A, 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ... (6 entities in total)
• 機能のキーワード: beta-barrel, binding protein, engineered lipocalin, transport protein-signaling protein complex, transport protein/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P31025 P15692
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59602.76

構造登録者

Giese, T.,Skerra, A. (登録日: 2014-05-04, 公開日: 2015-05-06, 最終更新日: 2023-09-20)

• 主引用文献: Giese, T.,Skerra, A.; Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold; To be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)