4Q9J
P-glycoprotein cocrystallised with QZ-Val
Summary for 4Q9J
Entry DOI | 10.2210/pdb4q9j/pdb |
Related | 4Q9H 4Q9I 4Q9K 4Q9L |
Related PRD ID | PRD_001235 |
Descriptor | Multidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID (2 entities in total) |
Functional Keywords | membrane protein, transporter, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Cell membrane; Multi-pass membrane protein: P21447 |
Total number of polymer chains | 4 |
Total formula weight | 144198.37 |
Authors | McGrath, A.P.,Szewczyk, P.,Chang, G. (deposition date: 2014-05-01, release date: 2015-03-04, Last modification date: 2024-07-10) |
Primary citation | Szewczyk, P.,Tao, H.,McGrath, A.P.,Villaluz, M.,Rees, S.D.,Lee, S.C.,Doshi, R.,Urbatsch, I.L.,Zhang, Q.,Chang, G. Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallogr.,Sect.D, 71:732-741, 2015 Cited by PubMed: 25760620DOI: 10.1107/S1399004715000978 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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