4Q6A

Staphylococcus aureus V31L, F98Y Mutant Dihydrofolate Reductase Complexed with NADPH

Summary for 4Q6A

Entry DOI	10.2210/pdb4q6a/pdb
Related	4Q67
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (5 entities in total)
Functional Keywords	oxidoreductase
Biological source	Staphylococcus aureus MUF168
Total number of polymer chains	1
Total formula weight	19313.60
Authors	Reeve, S.M.,Anderson, A.C. (deposition date: 2014-04-21, release date: 2014-12-31, Last modification date: 2023-09-20)
Primary citation	Reeve, S.M.,Gainza, P.,Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Protein design algorithms predict viable resistance to an experimental antifolate. Proc.Natl.Acad.Sci.USA, 112:749-754, 2015 Cited by PubMed: 25552560 DOI: 10.1073/pnas.1411548112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.099 Å)

Structure validation