4Q15
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Halofuginone and AMPPNP in space group P212121 at 2.35 A
Summary for 4Q15
Entry DOI | 10.2210/pdb4q15/pdb |
Related | 4NCX 4OLF |
Descriptor | Proline--tRNA ligase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total) |
Functional Keywords | structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, prolyl-trna synthetase, ligase |
Biological source | Plasmodium falciparum |
Cellular location | Cytoplasm : Q8I5R7 |
Total number of polymer chains | 2 |
Total formula weight | 120049.56 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2014-04-02, release date: 2016-04-20, Last modification date: 2023-09-20) |
Primary citation | Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C. Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 3:34-44, 2017 Cited by PubMed: 27798837DOI: 10.1021/acsinfecdis.6b00078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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