4Q15
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Halofuginone and AMPPNP in space group P212121 at 2.35 A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proline--tRNA ligase | polymer | 506 | 58986.5 | 2 | UniProt (Q8I5R7) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Plasmodium falciparum | Prolyl-tRNA synthetase, ProRS |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | E, H (A, B) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 5 | I, J, K (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A, B: 249 - 746 (UniProt: Q8I5R7)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | expression tag |
| Ala 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 117973.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2076.6 | |
| All* | Total formula weight | 120049.6 |
