4Q15

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Halofuginone and AMPPNP in space group P212121 at 2.35 A

4Q15 の概要

• エントリーDOI: 10.2210/pdb4q15/pdb
• 関連するPDBエントリー: 4NCX 4OLF
• 分子名称: Proline--tRNA ligase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, prolyl-trna synthetase, ligase
• 由来する生物種: Plasmodium falciparum
• 細胞内の位置: Cytoplasm : Q8I5R7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120049.56

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2014-04-02, 公開日: 2016-04-20, 最終更新日: 2023-09-20)

• 主引用文献: Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C.; Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.; Acs Infect Dis., 3:34-44, 2017; PubMed: 27798837; DOI: 10.1021/acsinfecdis.6b00078

実験手法

X-RAY DIFFRACTION (2.35 Å)