4Q0O
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Summary for 4Q0O
Entry DOI | 10.2210/pdb4q0o/pdb |
Related | 4Q0N |
Descriptor | Protein polybromo-1, POTASSIUM ION, (2E)-1-(2-hydroxyphenyl)-3-[(3R)-3-phenylpiperidin-1-yl]prop-2-en-1-one, ... (4 entities in total) |
Functional Keywords | pb1, polybromo 1 isoform 1, baf180, polybromo-1d, pbrm1, brg1-associated factor 180, bromodomain, chromatin regulator, dna-binding, nucleus, transcription, transcription regulation, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q86U86 |
Total number of polymer chains | 1 |
Total formula weight | 14994.48 |
Authors | Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-04-02, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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