4PZV
Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D
Summary for 4PZV
Entry DOI | 10.2210/pdb4pzv/pdb |
Related | 4F7V |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | ferredoxin-like fold; tim barrel fold, transferase, atp binding, phosphorylation |
Biological source | Francisella tularensis subsp. tularensis |
Total number of polymer chains | 1 |
Total formula weight | 49382.92 |
Authors | Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2014-03-31, release date: 2014-07-16, Last modification date: 2023-09-20) |
Primary citation | Shaw, G.X.,Li, Y.,Shi, G.,Wu, Y.,Cherry, S.,Needle, D.,Zhang, D.,Tropea, J.E.,Waugh, D.S.,Yan, H.,Ji, X. Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis. Febs J., 281:4123-4137, 2014 Cited by PubMed: 24975935DOI: 10.1111/febs.12896 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.704 Å) |
Structure validation
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