4PZV

Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D

4PZV の概要

• エントリーDOI: 10.2210/pdb4pzv/pdb
• 関連するPDBエントリー: 4F7V
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: ferredoxin-like fold; tim barrel fold, transferase, atp binding, phosphorylation
• 由来する生物種: Francisella tularensis subsp. tularensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49382.92

構造登録者

Shaw, G.X.,Shi, G.,Ji, X. (登録日: 2014-03-31, 公開日: 2014-07-16, 最終更新日: 2023-09-20)

• 主引用文献: Shaw, G.X.,Li, Y.,Shi, G.,Wu, Y.,Cherry, S.,Needle, D.,Zhang, D.,Tropea, J.E.,Waugh, D.S.,Yan, H.,Ji, X.; Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.; Febs J., 281:4123-4137, 2014; PubMed: 24975935; DOI: 10.1111/febs.12896

実験手法

X-RAY DIFFRACTION (1.704 Å)