4PY4

Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2

4PY4 の概要

• エントリーDOI: 10.2210/pdb4py4/pdb
• 分子名称: Poly [ADP-ribose] polymerase 14, 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide (3 entities in total)
• 機能のキーワード: rossmann fold, catalyze the post-translational modification of proteins, using b-nad+, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q460N5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44024.93

構造登録者

Li, J.,Xu, Y. (登録日: 2014-03-26, 公開日: 2015-04-01, 最終更新日: 2023-11-08)

• 主引用文献: Wang, P.,Li, J.,Jiang, X.,Liu, Z.,Ye, N.,Xu, Y.,Yang, G.,Xu, Y.,Zhang, A.; Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors; Tetrahedron, 70:5666-5673, 2017; DOI: 10.1016/j.tet.2014.06.064

実験手法

X-RAY DIFFRACTION (2.76 Å)