4PXA

DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V

Summary for 4PXA

Entry DOI	10.2210/pdb4pxa/pdb
Related	4PX9
Descriptor	ATP-dependent RNA helicase DDX3X, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION (3 entities in total)
Functional Keywords	dead-box helicase, hydrolase, translation, rna binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus speckle: O00571
Total number of polymer chains	1
Total formula weight	53592.95
Authors	Epling, L.B.,Grace, C.R.,Lowe, B.R.,Partridge, J.F.,Enemark, E.J. (deposition date: 2014-03-22, release date: 2015-03-11, Last modification date: 2023-09-20)
Primary citation	Epling, L.B.,Grace, C.R.,Lowe, B.R.,Partridge, J.F.,Enemark, E.J. Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427:1779-1796, 2015 Cited by PubMed: 25724843 DOI: 10.1016/j.jmb.2015.02.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation