4PXA

DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ATP-dependent RNA helicase DDX3X	polymer	467	52690.9	1	UniProt (O00571) Pfam (PF00270) Pfam (PF00271) In PDB	Homo sapiens (human)	DEAD box protein 3, X-chromosomal, DEAD box, X isoform, Helicase-like protein 2, HLP2
2	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	A	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)

Sequence modifications

A: 135 - 582 (UniProt: O00571)

PDB	External Database	Details
Met 116	-	expression tag
Gly 117	-	expression tag
Ser 118	-	expression tag
Ser 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
Ser 126	-	expression tag
Ser 127	-	expression tag
Gly 128	-	expression tag
Leu 129	-	expression tag
Val 130	-	expression tag
Pro 131	-	expression tag
Arg 132	-	expression tag
Gly 133	-	expression tag
Ser 134	-	expression tag
Val 354	Asp 354	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52690.9
Non-Polymers*	Number of molecules	6
	Total formula weight	902.1
All*	Total formula weight	53592.9

*Water molecules are not included.