4PX3

Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate

Summary for 4PX3

• Entry DOI: 10.2210/pdb4px3/pdb
• Related: 4PX2 4PX5
• Descriptor: Glucokinase regulatory protein, N-[(R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: sis domain containing protein, regulatory protein - binds to and inhibits glucokinase, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q14397
• Total number of polymer chains: 2
• Total formula weight: 146108.36

Authors

Jordan, S.R.,Chmait, S. (deposition date: 2014-03-21, release date: 2015-05-13, Last modification date: 2023-09-20)

• Primary citation: Pennington, L.D.,Bartberger, M.D.,Croghan, M.D.,Andrews, K.L.,Ashton, K.S.,Bourbeau, M.P.,Chen, J.,Chmait, S.,Cupples, R.,Fotsch, C.; Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding; To be Published,

Experimental method

X-RAY DIFFRACTION (2.43 Å)