4PX5
Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate
Summary for 4PX5
Entry DOI | 10.2210/pdb4px5/pdb |
Descriptor | Glucokinase regulatory protein, N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total) |
Functional Keywords | sis domain containing protein, regulatory protein - binds to and inhibits glucokinase, glucokinase, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q14397 |
Total number of polymer chains | 2 |
Total formula weight | 146922.29 |
Authors | Jordan, S.R.,Chmait, S. (deposition date: 2014-03-21, release date: 2015-05-13, Last modification date: 2023-09-20) |
Primary citation | Pennington, L.D.,Bartberger, M.D.,Croghan, M.D.,Andrews, K.L.,Ashton, K.S.,Bourbeau, M.P.,Chen, J.,Chmait, S.,Cupple, R.,Fotsch, C. Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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