4PX5

Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase regulatory protein	polymer	638	70306.6	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	GKRP, Glucokinase regulator
2	C, V (A, B)	N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide	non-polymer		547.1	2	Chemie (2WZ)
3	D, W (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	31	Chemie (IOD)
5	NA, OA, T (B, A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	PA, QA, RA, SA, U (B, A)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
7	TA, UA (A, B)	water	water		18.0	127	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -11	-	expression tag
Ala -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Gly 626	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140613.2
Non-Polymers*	Number of molecules	43
	Total formula weight	6309.1
All*	Total formula weight	146922.3

*Water molecules are not included.