Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4PX2

Human GKRP bound to AMG2882 and Sorbitol-6-Phosphate

Summary for 4PX2
Entry DOI10.2210/pdb4px2/pdb
Related4PX3 4PX5
DescriptorGlucokinase regulatory protein, N-[(R)-1-benzofuran-2-yl(phenyl)methyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
Functional Keywordssis domain containing protein, regulatory protein - binds to and inhibits glucokinase, glucokinase, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q14397
Total number of polymer chains2
Total formula weight146222.37
Authors
Jordan, S.R.,Chmait, S. (deposition date: 2014-03-21, release date: 2015-05-13, Last modification date: 2023-09-20)
Primary citationPennington, L.D.,Bartberger, M.D.,Croghan, M.D.,Andrews, K.L.,Ashton, K.S.,Bourbeau, M.P.,Chen, J.,Chmait, S.,Cupples, R.,Fotsch, C.
Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding
To be Published,
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon