4PVF

Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution

4PVF の概要

• エントリーDOI: 10.2210/pdb4pvf/pdb
• 分子名称: Serine hydroxymethyltransferase, mitochondrial, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: hydroxymethyltransferase, aat-like fold, one carbon metabolism, transferase, 5-formyl-thf, methylase, mitochondrial
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion : P34897
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107800.19

構造登録者

Giardina, G.,Brunotti, P.,Fiascarelli, A.,Contestabile, R.,Cutruzzola, F. (登録日: 2014-03-17, 公開日: 2015-01-28, 最終更新日: 2023-12-06)

• 主引用文献: Giardina, G.,Brunotti, P.,Fiascarelli, A.,Cicalini, A.,Costa, M.G.,Buckle, A.M.,di Salvo, M.L.,Giorgi, A.,Marani, M.,Paone, A.,Rinaldo, S.,Paiardini, A.,Contestabile, R.,Cutruzzola, F.; How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.; Febs J., 282:1225-1241, 2015; PubMed: 25619277; DOI: 10.1111/febs.13211

実験手法

X-RAY DIFFRACTION (2.6 Å)