4PUZ

Crystal structure of spleen tyrosine kinase (Syk) in complex with GS-9973

Summary for 4PUZ

• Entry DOI: 10.2210/pdb4puz/pdb
• Related: 4PV0
• Descriptor: Tyrosine-protein kinase SYK, 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine (3 entities in total)
• Functional Keywords: syk, spleen tyrosine kinase, kinase inhibitor, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane (Probable): P43405
• Total number of polymer chains: 2
• Total formula weight: 68590.93

Authors

Lansdon, E.B.,Mitchell, S.A. (deposition date: 2014-03-14, release date: 2014-04-23, Last modification date: 2023-09-20)

• Primary citation: Currie, K.S.,Kropf, J.E.,Lee, T.,Blomgren, P.,Xu, J.,Zhao, Z.,Gallion, S.,Whitney, J.A.,Maclin, D.,Lansdon, E.B.,Maciejewski, P.,Rossi, A.M.,Rong, H.,Macaluso, J.,Barbosa, J.,Di Paolo, J.A.,Mitchell, S.A.; Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase.; J.Med.Chem., 57:3856-3873, 2014; PubMed: 24779514; DOI: 10.1021/jm500228a

Experimental method

X-RAY DIFFRACTION (2.085 Å)