4PUZ

Crystal structure of spleen tyrosine kinase (Syk) in complex with GS-9973

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase SYK	polymer	291	33884.0	2	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (human)	Spleen tyrosine kinase, p72-Syk
2	A, B	6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	non-polymer		411.5	2	Chemie (CG9)
3		water	water		18.0	112	Chemie (HOH)

Sequence modifications

A, B: 353 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	Ala 353	conflict
Ala 354	Asp 354	conflict
Leu 355	Pro 355	conflict
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67768.0
Non-Polymers*	Number of molecules	2
	Total formula weight	822.9
All*	Total formula weight	68590.9

*Water molecules are not included.