4PUO

Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine

Summary for 4PUO

• Entry DOI: 10.2210/pdb4puo/pdb
• Related: 1HYS 3V4D 3V4I 3V81 4PQU 4PWD 4Q0B
• Descriptor: HIV-1 Reverse Transcriptase, p66 subunit, HIV-1 Reverse Transcriptase, p51 subunit, 5'-R(P*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3', ... (5 entities in total)
• Functional Keywords: fingers, palm, thumb, connection, rnase h, nucleotidyltransferase, dna-directed dna polymerase, rna-directed dna polymerase, nuclease, ribonuclease h, trna, transferase, hydrolase-dna-rna-inhibitor complex, hydrolase/dna/rna/inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 8
• Total formula weight: 259007.19

Authors

Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2014-03-13, release date: 2014-06-18, Last modification date: 2023-09-20)

• Primary citation: Das, K.,Martinez, S.E.,Bandwar, R.P.,Arnold, E.; Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.; Nucleic Acids Res., 42:8125-8137, 2014; PubMed: 24880687; DOI: 10.1093/nar/gku487

Experimental method

X-RAY DIFFRACTION (2.901 Å)