4PUL
tRNA-Guanine Transglycosylase (TGT) Mutant D102N in Complex with 6-Amino-2-(methylamino)-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one
Summary for 4PUL
Entry DOI | 10.2210/pdb4pul/pdb |
Related | 1P0D 4PUJ 4PUK 4PUM 4PUN |
Descriptor | Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase, guanine exchange enzyme, guanine, preq1, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis |
Total number of polymer chains | 1 |
Total formula weight | 43312.45 |
Authors | |
Primary citation | Neeb, M.,Czodrowski, P.,Heine, A.,Barandun, L.J.,Hohn, C.,Diederich, F.,Klebe, G. Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pKa Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme. J.Med.Chem., 57:5554-5565, 2014 Cited by PubMed: 24955548DOI: 10.1021/jm500401x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.654 Å) |
Structure validation
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