4PUF

Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1

Summary for 4PUF

Entry DOI	10.2210/pdb4puf/pdb
Descriptor	E3 ubiquitin-protein ligase SlrP, Thioredoxin (2 entities in total)
Functional Keywords	lrr domain, nel domain, e3 ubiquitin ligase, human thioredoxin 1, ligase -oxidoreductase complex, ligase-oxidoreductase complex, ligase/oxidoreductase
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Cellular location	Secreted: D0ZRB2 Nucleus: P10599
Total number of polymer chains	4
Total formula weight	172247.14
Authors	Zouhir, S.,Bernal-Bayard, J.,Cordero-Alba, M.,Cardenal-Munoz, E.,Guimaraes, B.,Lazar, N.,Ramos-Morales, F.,Nessler, S. (deposition date: 2014-03-13, release date: 2014-09-17, Last modification date: 2024-02-28)
Primary citation	Zouhir, S.,Bernal-Bayard, J.,Cordero-Alba, M.,Cardenal-Munoz, E.,Guimaraes, B.,Lazar, N.,Ramos-Morales, F.,Nessler, S. The structure of the Slrp-Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family. Biochem.J., 464:135-144, 2014 Cited by PubMed: 25184225 DOI: 10.1042/BJ20140587 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.296 Å)

Structure validation