4PRT

Human Aldose Reductase complexed with Schl12221 ({2-[5-(3-NITROPHENYL)FURAN-2-YL]PHENYL}ACETIC ACID) at 0.96 A

Summary for 4PRT

• Entry DOI: 10.2210/pdb4prt/pdb
• Related: 2IKG 2IKH 3DN5 4NKC 4PR4 4PRR
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[5-(3-nitrophenyl)furan-2-yl]phenyl}acetic acid, ... (4 entities in total)
• Functional Keywords: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36965.04

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-03-06, release date: 2015-04-08, Last modification date: 2023-09-20)

• Primary citation: Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G.; Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase; To be Published,

Experimental method

X-RAY DIFFRACTION (0.96 Å)